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OCT Biomarkers for Diabetic Retinopathy

January 17, 2020

Overview

In this study, investigators are seeing if standard optical coherence tomography (OCT) might be useful for evaluating diabetic retinopathy. Currently the gold standard for detecting vascular changes that cause diabetic retinopathy is fluorescein angiography (FA) but FA requires an injection of a dye into the vein of the patient’s arm which can cause side effects. This is why investigators are hoping to find an alternate evaluation method.

 

Study Information

Participants will be divided into three groups – one with diabetes and severe diabetic retinopathy, one with diabetes and without or with mild diabetic retinopathy, and a control group without diabetes or any form of eye disease. The groups will then be monitored for retinal blood flow, capillary dropout and/or new abnormal retinal blood vessel growth, and measurable macular edema by OCT angiography and imaging.

 

Inclusion Criteria

 

  • Male or female participants 18-79 years old
  • With Type 1 diabetes for over 5 years or Type 2 diabetes of any duration (for the diabetes group only)

 

Exclusion Criteria

 

  • Vision worse than 20/200
  • Inability to maintain fixation for OCT imaging
  • Significant kidney disease, kidney failure or kidney transplant
  • Unstable medical status, including blood pressure greater than 180/110 or unstable heart disease
  • Pregnant or nursing an infant
  • Presence of an eye disease (other than diabetic retinopathy) that can affect retinal blood flow, retinal permeability or retinal anatomy
  • Significant cataract, corneal scar, vitreous bleed or other media opacity
  • History of major eye surgery within 4 months prior to enrollment in this study

 

Location

Oregon Health & Science University

Portland, Oregon, United States, 97239

Contact: David Poole, COT    503-494-8024 pooleb@ohsu.edu  

Contact: Denzil Romfh, OD    503-494-4351 romfhd@ohsu.edu  

Principal Investigator: Thomas Hwang, MD    

 

Sponsors/Collaborators

Oregon Health and Science University

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