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Senofilcon A Lenses in Moderate to Severe Dry Eye Disease

January 17, 2020


In this clinical trial, investigators are studying how Senofilcon A daily contact lenses affect the treatment of moderate to severe dry eye. Researchers will compare signs and symptoms before and after treatment.


Study Information

In the study, investigators will enroll 32 patients who have moderate to severe dry eye and have them use soft contact lenses made of Senofilcon A. They will also fill out a questionnaire.


Inclusion Criteria


  • Confirmed diagnosis of moderate to severe dry eye associated with either Graft-versus-host disease (GVHD), Sjogren syndrome, idiopathic dry eyes, or minimal limbal cell deficiency
  • A baseline Schirmer tear test (1) of less than 5 mm at 5 minutes without anesthesia
  • Have a visual analog score for comfort of 50 or less (scale of 1-100, with 100 meaning perfect ocular comfort and 1 meaning severe ocular pain)
  • Ability or the resources to insert and remove the study lenses
  • An OSDI score greater than 42
  • A willingness to sign an informed consent


Exclusion Criteria


  • No dry eyes or mild dry eyes
  • A baseline Schirmer tear test (1) of greater than 5 mm of wetting at 5 minutes
  • Dry eye comfort score of greater than 50 on a visual analog scale
  • Unable to insert or remove the study lenses (or have a family member do so)
  • Have an OSDI score less than 42
  • Has been diagnosed with neurotrophic keratopathy in either eye
  • Unwilling to enroll in the study, and unwilling to provide signed informed consent to participate in the study



University of Illinois at Chicago

Chicago, Illinois, United States, 60612

Contact: Jacob Merriman    312-996-8041   



University of Illinois at Chicago

Johnson & Johnson Vision Care, Inc.

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